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Developmental and Reproductive Toxicology (DART) Studies
Comprehensive, state-of-the-art DART and NHP DART services to help you make smarter decisions faster.
Next Generation Capabilities, to Keep the Next Generation Safe.
Extensive NHP DART experience with 120+ studies in pregnant NHPs and 25+ (e)PPND studies
Social housing is standard for NHP DART studies
DART expertise and capacity with more than 70 studies conducted in small models each year
全球能力和专业知识接管任何飞镖或NHP-DART研究。
As the industry recognized leader in developmental and reproductive toxicology (DART and NHP-DART) we have extensive specialized experience across various animal models and species. We’ve completed more than 120 NHP-DART studies in pregnant models and performed more than 25 ePPND/PPND studies. In addition, we conduct more than 70 DART studies each year in small models.
When it comes to capacity — our Greenfield (USA) and Harrogate (Europe) GLP sites offer spacious modern facilities for a variety of DART studies. Our Münster (Europe) and Madison (USA) GLP sites boast DART and Nonhuman Primate (NHP) DART capabilities in various housing configurations, including social housing and our novel 3-Pillar approach to NHP studies in European-compliant housing. In fact, social housing is a minimum standard for NHP DART studies.
我们的全球高级工作人员根据世界着名的飞镖科学家Gerhard Weinbauer博士，包括10多名专门的Dart研究董事，在Dart，NHP-Dart和一般毒理学中具有深刻的经验，其中许多都有博士学位。或高级度。
Get your NHP DART studies started, with fewer delays.
NHP DART studies are some of the most challenging given the inherent conception risks. We offer advancements in NHP DART studies, such as EU-compliant housing and our novel 3-Pillar approach, which has resulted in higher than average conception rates and lower than average pre- and post-natal losses. These advancements translate into less overall risk, better adherence to your timelines and an overall higher ROI for you.
最新的technology and techniques — deliver welfare and enrichment.
我们知道您的学习的每一个细节都很重要。这就是为什么我们致力于在动物福利和丰富的进步，使您的飞镖和/或NHP DART计划受益。我们首先提供各种适合的住房 - 从固有底部拍摄，到社交住房和符合欧盟的配置 - 我们的选择使模型舒适和丰富，转化为敏感数据收集，以确切地位了解您的影响新化合物。
In addition, we are pioneers in advancing NHP DART studies through a unique “Three-Pillar Approach” that was developed and refined at our Münster, Germany (Europe) and offered at both our Münster and Madison NHP Centers of Excellence. Our “Three-Pillar Approach” provides an enhanced housing design that exceeds EU guidelines for minimum cage dimensions, a rigorous training program for both animals and staff, and systematic cage mate selection that is based on model behavior, for improved social pairing.
为了解决特殊的学习要求，我们还开创了其他尖端创新和技术的使用。以下只是一些例子。具有未镇静使用超声的成像可以帮助消除在您的学习结果中麻醉的潜在影响。连续输注可以帮助满足您的专业送货要求 - 即使是最小的啮齿动物。使用任何迷宫或乙型技术进行定量行为监测，可以帮助您评估神经兽性终点，即使使用自由移动模型。
Further, the study segments can be performed separately or as a single study in any combination — depending on your specific needs. As your partner, we consult with you on fit-for-purpose study design to keep your DART or NHP DART program on track.
A partner for the long road ahead.
Dart可以是您的药物开发旅程的长期，复杂，昂贵的部分。您需要一个具有专门的生殖和发育毒理学经验的合作伙伴，有效地设计和进行学习;创新的技术和能力使您能够有效地满足您的时间表;和监管专业知识浏览指南并确保您符合要求的所有要求。