建模与药物测定学

药物测量学是使用数学模型来描述和表征异卵生物和生物系统的相互作用。药物测量学通过在Covance的许多工具中使用,包括非隔间和隔间药代动力学分析,基于生理学的药代动力学模型(PBPK),整合通过PK / PD模型的药代动力学, in silico DDI assessment and custom systems pharmacology models.

Computational & In Silico Pharmacometrics

药效测学可以帮助更好地预测pharmacokinetics (PK), drug response (PD) and药物互动(DDIs). The ability to predict these aspects of your molecule in development can help you to develop a streamlined program to enable moving quickly from discovery to development.

In addition, it can also help you build better and more efficient study designs to save time and money. We can help you in the exploration of how pharmacometrics can lead you to the next stage of your drug development program as well as implement the tools necessary to bring you the results that you need.

Computational modeling & pharmacometrics

A隔间PK模型通常比非组件PK模型更复杂,并且当实验参数改变时,允许预测隔室之间的建模轮廓。隔间PK适用于大型和小分子。

PK / PD造型为PK和PD学科创建一组数学表达式,以便更好地了解分子的剂量强度随着时间的推移而变化。因此,PK / PD建模允许您更好地评估ADME属性,建立安全利润率并评估剂量变化要求。PK / PD建模通常用于隔间PK研究以及人口PK研究。

PBPK modeling通过监管机构更常见的是通知临床研究设计的一种方式,也用作比较来自多种毒品候选者的治疗适应症的方法。PBPK建模确实需要一组体外in vivo数据验证模型。

量化和/或系统药理学(QSP / SP)建模, a subdiscipline of pharmacokinetics, is an approach that integrates preclinical mechanistic evidence and physiological system models to investigate and predict drug response.

WEBINAR RECORDING

PBPK建模支持临床DDI研究

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POSTER

PBPK modeling for optimization of sustained-release orthodontic retainer of Clonidineto

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WEBINAR RECORDING

Understanding FDA regulations & applying in vitro & PBPK modeling techniques

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