发育和生殖毒理学(DART)研究

Comprehensive, state-of-the-art DART and NHP DART services to help you make smarter decisions faster.

  • Extensive NHP DART experience with 120+ studies in pregnant NHPs and 25+ (e)PPND studies

  • Social housing is standard for NHP DART studies

  • DART expertise and capacity with more than 70 studies conducted in small models each year

Photo of a Covance DART scientist performing a study with a microsope.
你的需要

随着行业公认的发展and reproductive toxicology (DART and NHP-DART) we have extensive specialized experience across various animal models and species. We’ve completed more than 120 NHP-DART studies in pregnant models and performed more than 25 ePPND/PPND studies. In addition, we conduct more than 70 DART studies each year in small models.

当涉及到容量 - 我们的格林菲尔德(美国)和哈罗盖特(欧洲)GLP网站为各种飞镖研究提供宽敞的现代化设施。我们的Münster(欧洲)和麦迪逊(美国)GLP网站拥有飞镖和非人类的灵长类动物(NHP)在各种住房配置中的DART功能,包括社会住房和我们符合欧洲符合住房的NHP研究的新型3支柱方法。事实上,社会住房是NHP DART研究的最低标准。

我们的全球高级员工在世界著名的DART科学家Gerhard Weinbauer博士的领导下,包括10多名在DART、NHP-DART和一般毒理学方面具有丰富经验的专门的DART研究主管,其中许多人拥有博士或高级学位。

NHP DART studies are some of the most challenging given the inherent conception risks. We offer advancements in NHP DART studies, such as EU-compliant housing and our novel 3-Pillar approach, which has resulted in higher than average conception rates and lower than average pre- and post-natal losses. These advancements translate into less overall risk, better adherence to your timelines and an overall higher ROI for you.

我们知道每个细节对你的学习都很重要。这就是为什么我们致力于动物福利和丰富的开拓性进展,使您的DART和/或NHP DART计划受益。我们首先提供各种适合用途的住房-从坚固的底部封闭,社会住房和符合欧盟的配置-我们的选择使模型舒适和丰富,转化为敏感的数据收集,精确了解您的新化合物的影响。

In addition, we are pioneers in advancing NHP DART studies through a unique “Three-Pillar Approach” that was developed and refined at our Münster, Germany (Europe) and offered at both our Münster and Madison NHP Centers of Excellence. Our “Three-Pillar Approach” provides an enhanced housing design that exceeds EU guidelines for minimum cage dimensions, a rigorous training program for both animals and staff, and systematic cage mate selection that is based on model behavior, for improved social pairing.

为了满足特殊的学习要求,我们还率先采用了其他前沿创新和技术。以下只是几个例子。在未镇静的情况下使用超声成像可以帮助消除研究结果中麻醉的潜在影响。持续输液可以帮助满足您的特殊分娩要求-即使是最小的啮齿动物。任何迷宫或EthoVision技术的定量行为监测,都可以帮助你评估神经行为终点,即使是自由移动模型。

Further, the study segments can be performed separately or as a single study in any combination — depending on your specific needs. As your partner, we consult with you on fit-for-purpose study design to keep your DART or NHP DART program on track.

我们的能力

DART可能是药物开发过程中漫长、复杂和昂贵的一部分。您需要一个具有专门生殖和发育毒理学经验的合作伙伴,以有效地设计和执行您的研究;创新技术和能力,使您能够有效地满足您的时间表;以及管理诀窍,以指导方针,并确保您符合所有要求。