采用细胞疗法(ACT)和汽车T细胞

With over 80 unique hematological malignancy cell lines, such as the CD19+Raji-Luc.lymphoma model, theMV-411-Luc白血病模型,和mm.1s-luc.multiple myeloma model, we lead the industry with market-relevant models for your studies. We also have an ever-expanding list of solid tumor models validated in NSG mice to support the field’s drive toward approval of an adoptive cell therapy (ACT) in a solid tumor indication.

在使用小鼠肿瘤模型来评估采用细胞疗法(行为)时发现无与伦比的经验。具有广泛的传播和皮下肿瘤模型,其特征在于NSG小鼠,以及一个知悉如何应用它们的科学团队,我们可以指导为您的汽车T细胞或其他行为研究选择正确的肿瘤模型。

肿瘤模型以NSG小鼠为特征

Models (Currently Available)
Model 组型
22Rv1 Prostate carcinoma
H-1299 Non-small cell lung carcinoma
HEP 3B2.1-7 Hepatocellular carcinoma
KG-1-LUC-MCH-PURO Myeloid leukemia
MM1.S (pMMP-Luc-Neo) Plasma cell myeloma
MOLM-13 Plasma cell myeloma
MV4-11-FUW-Luc-mCh-Puro Acute monocytic leukemia (AML)
纳尔马6.-Luc-mCh-Puro Lymphoblastic leukemia
NCI-H929-LUC-MCH-PURO Plasma cell myeloma
PC-3 Prostate carcinoma
Raji-Luc. 淋巴瘤
RPMI-8226. Plasma cell myeloma
SK-MEL-28 Melanoma
SK-OV-3-Luc-D3 & SK-OV-3 卵巢腺癌
Snu-5. 胃癌
U-251-Luc-mCh-Puro 胶质母细胞瘤
Models (In Progress)
Model 组型
A549 Non small cell lung carcinoma
BT-20 乳腺导管癌
BT-474 乳腺导管癌
BxPC-3 胰腺腺癌
H-1299 Non-small cell lung carcinoma
Jurkat. Lymphoblastic leukemia
MDA-MB-231-LUC-D3H2LN 乳腺癌
NCI-H1703 鳞状细胞肺癌
NCI-H1975 肺adenocarcinoma
SK-BR-3 乳腺腺癌

肿瘤模型通过组织型,针对养殖细胞疗法

血液恶性肿瘤:

急性髓性白血病
白血病[AML]
EOL-1
Kasumi-3
Kasumi-3-Luc-mCh-Puro
KG-1-LUC-MCH-PURO
MOLM-13
MV-4-11
NOMO-1
human
C1498
B-cell Malignancies
白血病[b-全]
纳尔马6.
纳尔马6.-Luc-MCh-Puro
REH.
RS4; 11.
human
淋巴瘤[B细胞]
D B
D B/M2
human
A20
淋巴瘤[B-NHL]
Farage
Granta-519
human
淋巴瘤[Burkitt’s]
B-JAB
Daudi
namalwa.
raji.
Ramos-Luc
human
淋巴瘤[DLBCL]
OCI-Ly1 LN
OCI-Ly19-Luc-Neo
OCI-LY3-LUC-MCH-PURO
OCI-Ly7-Luc-mCh-Puro (rescued)
OCI-Ly7-Luc-Neo
Pfeiffer
SU-DHL-10-LN高
SU-DHL-16
SU-DHL-4-LUC-MCH-PURO
SU-DHL-8
TMD8
托莱多 - 卢克 - 诺伊
WSU-DLCL2.
human
Multiple Myeloma
骨髓瘤
JJN-3-Luc
NCI-H929
OPM-2
RPMI 8226.
U266B1.
human
J558

实体瘤:

胶质母细胞瘤多形形
BT142
dbtrg(肿瘤)
D BTRG-05MG
Gli36-DsRed-R-Luc (rescued)
LN-18
LN-229.
M059K.
SF-295
SF-539
SF-767
SNB-19
U-87 MG
U251
human
GL261
肝细胞癌
HEP 3B2.1-7
HEP G2.
human
BNL 1ME A.7R.1.
BNL 1ME A.7R.1-LUC-MCH-PURO
hep55.1c
HEPA 1-6-Luc-mCh-Puro
LL / 2-LUC-M38
肺[腺嘌呤]
NCI-H596.
human
肺[气塑性癌]
Calu-6.
human
肺[Bronchioalveolar]
NCI-H322M
human
肺[NSCLC]
A549-LUC-C8
Calu-1
Calu-3.
HCC827
HCC827-Luc-mCh-Puro
NCI-H125
NCI-H125-Luc
NCI-H1299
NCI-H1650
NCI-H1703
NCI-H1703-Luc-mCh-Puro
NCI-H1975-LUC
NCI-H2110
NCI-H2122
NCI-H441
NCI-H460-LUC2
NCI-H522
PC-9
human
肺[SCLC]
DMS 114.
NCI-H446
NCI-H69.
NCI-H82
SHP-77.
human
肺[鳞状]
EBC-1
SK-MES-1
human
Mammary/Breast
Mammary/Breast
BT-20
BT-474
Hs 578Bst
Hs 578T
MCF 10A
MCF7-LUC-MCH-PURO
MDA-MB-231-2LMP
MDA-MB-231-Luc-D3H1
MDA-MB-231-Luc-D3H2
MDA-MB-231-Luc-D3H3
MDA-MB-361
MDA-MB-453
MDA-MB-468
MX-1-LUC
SK-BR-3
T47D.
human
mmtv-pymt.
卵巢癌
Ovarian
A2780-Luc
IGROV1-Luc-Mch-Puro
NIH:OVCAR-3
NIH:OVCAR-3-Luc-mCh-Puro
OV-90.
OVCAR-4
OVCAR-5-Luc-mCh-Puro
OVCAR-8-Luc-mCh-Puro
SK-OV-3
human
ID8
前列腺癌
Prostate
22Rv1
CWR-22-R
DU 145-Luc
LnCap clone FGC
PC-3-LUC
PC-3M-Luc-C6
VCaP
human