Custom Antibody Reagents

Providing you with an end-to-end service to generate antibody reagents against a variety of antigen types in a broad range of host species.

Custom Antibody Capabilities

For nearly five decades, we’ve been refining services and capabilities to help you manage the entire antibody development process.

Choose from a comprehensive set of suite of services including:

  • Polyclonal & monoclonal antibody production
  • Purification, labeling and characterization of antibodies
  • Hybridoma generation, characterization and scale-up of non-GLP assay qualification and sample analysis
文件

从一个完整的定制工具和关键抗体试剂开发服务组合中进行选择,同时执行其他任务nonclinical studies在科文斯。我们提供区域和全球解决方案,帮助您访问:

  • 具有丰富支持经验的敬业团队大的and small molecule development
  • LC-MS在生物治疗分析方面的专业知识,为您提供大分子研究所必需的效率、选择性和鲁棒性
  • Innovative technology platforms such as Gyros™, MSD, ELISA, AB Sciex, Hamilton Star® and Bio-Plex® to deliver efficient quality results
  • Integrated生物分析溶液以支持非监管和监管非临床数据的发现和安全评估

Tool Antibody Reagents

Tool antibody reagents are standard antibody generation services for use in characterization of the target in basic/academic settings or exploratory drug discovery research.

服务包括从几毫克到大量的单克隆和多克隆抗体生产。

关键抗体试剂

Critical antibody reagents are used in a regulated drug development setting and include both polyclonal and monoclonal anti-drug antibodies, anti-idiotypic antibodies and anti-host cell protein antibodies. These reagents are generated with extensive documentation, additional levels of characterization and often larger quantities to last for the duration of the product's lifecycle.


多克隆抗体

定制抗体服务的完整组合包括肽合成、抗体生产、接合、纯化、标记和表征。多克隆抗体的产生涉及免疫、免疫应答监测和抗原特异性亲和纯化三个阶段。每一步都是可定制的,我们将与您合作创建一个优化的生产计划,以最大限度地提高血清量和抗体滴度。

Monoclonal Antibodies

A full range of production services are available in diverse rodent strains. You can choose in vivo或在体外生产协议和适应的公关otocols for small or large quantities depending on your needs.

Anti-Idiotype Antibodies

As leading providers in custom anti-ID antibody development, our teams will bring unique scientific expertise to your anti-ID project such as:

  • 生物疗法与大分子
  • 全长或截短抗体
  • F(ab')2、Fab和单链抗体片段

By partnering with us, you will benefit from our extensive capabilities in generating capture reagents forPK/TK studies中和试验和抗原显像阳性对照。

Hybridomas

Generate hybridomas against a large array of antigens and keep all cell lines developed by Covance as your exclusive property. Also, all four hybridoma development stages – immunization, fusion and screening, subcloning and clone stabilization – are customizable.

With extensive in体外/体内放大能力,以适应任何规模的项目,您可以体验到一系列额外的免疫服务。这些包括细胞系扩增、PBMC分离、同型和支原体检测。

Anti-Host Cell Protein Antibodies (Anti-HCP)

由于重组蛋白制剂中含有宿主细胞蛋白可能会损害产品的安全性和质量,因此将这种污染降至最低水平至关重要。

抗HCP抗体开发包括用于捕获和检测的体内阶段和用于纯化、表征和接合的体外阶段。第一阶段是由我们丰富的内部经验与多个品种的支持,所以你可以选择最好的模式,以满足您的独特要求。对于第二阶段,我们专门的免疫化学实验室提供了多种可定制的选择。

We can help you every step of the way, with our custom reagent and method development for anti-HCP assays:

  • Custom reagent and method development
  • 分析开发/瓦里dation (ELISA)
  • 鉴定和确认
  • 例行试验
  • 化验转移

Anti-Drug Antibodies

By partnering with leading providers of custom ADA development, you will benefit from our scientific expertise across the development process as well as our extensive capabilities in custom reagent development and related ADA services, including development of PK, TK, and potency assays.

Our key skills involve generating positive control for PK/TK studies and capture reagents for potency assays. We have a dedicated immunochemistry lab providing protein A/G and/or antigen-specific purifications, along with various options for depleting cross-reactive antibodies.

无论您的目标是方法或基质验证,还是评估药物耐受性、分析敏感性或所需的最低稀释度,您都可以从这些分子类型的全套ADA功能中进行选择,例如:

  • 生物疗法与大分子
  • 全长或截短抗体
  • Various adjuvants