Clinical Pathology

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While anatomic pathologists examine tissue samples, clinical pathologists focus on blood, bodily fluids, tissue and microscopic cell evaluation (such as bone marrow).

Our veterinary clinical pathologists and medical technologists provide GLP/GCP results for discovery, preclinical and clinical research.

Clinicalpathologistsclosely monitor animal health in collaboration with veterinarians and provide consultation to toxicologists and study directors during protocol development and during the study, advising on appropriate tests and biomarkers for inclusion. In addition, all clinical pathology contributor reports are authored by board-certified clinical pathologists.

Clinical Pathology Study Support

  • 一个nalytic evaluations on samples, collected from living humans and animals
  • Fluid examinations
  • Multiple collections during a study (depending on species)
  • Toxicologyand histopathology findings correlations
  • Nonclinical or clinical pathology study (see clinical testing services)

Common Evaluations for Clinical Pathology

Hematology & Coagulation

  • 红细胞计数、血红蛋白和血细胞比容
  • MCV, MCH, MCHC, RDW
  • White blood cell count
  • 一个bsolute differential white blood cell count
  • Platelet count, MPV
  • 一个bsolute reticulocyte count
  • Blood cell smear (or blood cell morphology)
  • Prothrombin time (PT)
  • 一个ctivated partial thromboplastin time (APTT)
  • Fibrinogen

Urinalysis & Urine Chemistry

  • Volume, usually overnight (e.g., 16 or 24 hours)
  • 一个ppearance (color and turbidity)
  • 比重(或同渗重摩)
  • Reagent strip tests: pH, protein, occult blood, glucose, ketones, bilirubin.
  • Microscopic exam of sediment: RBCs, WBCs, epithelial cells, casts, crystals, bacteria, sperm.
  • Urine Chemistry - not done routinely (any species)
  • Electrolytes or other urine analytes

Clinical Chemistry

  • Glucose
  • Urea nitrogen, creatinine
  • Total protein, albumin, globulin, A/G ratio
  • Cholesterol, triglycerides
  • Total bilirubin
  • 一个lanine aminotransferase (ALT), Alkaline phosphatase ALP), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT)
  • Creatine kinase (CK)
  • Calcium, inorganic phosphorus
  • Sodium, potassium, chloride

Other

  • Bone marrow smear exam: myeloid:erythroid (M:E ratio); qualitative cytologic exam (subjective assessment); quantitative (full or modified myelogram using 200 or 500 cell differential)
  • Other body fluids: cell counts and cytology using cytospin preparation: CSF, synovial, ocular fluids
  • 一个dditional biomarkers:
    • Liver
    • Cardiac
    • Renal (kidney)
    • Muscle
  • Markers of inflammation including cytokines and acute phase proteins
  • Consult Clinical Pathologists for other non-routine test requests

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