Computed Tomography (CT)

Micro computed tomography (CT) imaging platform draws on expertise in implementing, developing, optimizing, and validating micro-CT imaging paradigms for drug research studies. Our experience in CT-based bone and soft tissue imaging encompasses a number ofdisease states.

In vivo micro-CT imaging enables high-resolution (to ~50 microns), three-dimensional image generation by rotation of an x-ray source and detector around an imaging subject. Multiple projections are obtained during the rotation and reconstructed to generate the three-dimensional image. The large density differences between bone, soft tissue, and air make them readily distinguished by CT. CT contrast between different soft tissues is generally more subtle. The use of systemically administered, CT contrast agents enables better visualization of the soft tissues, including the vascular system.


CT is the preferred, translational technology for the quantification of metastatic and arthritic bone disease. We provide numerous, validated bone-disease models, including several models of bone metastasis and rheumatoid arthritis. Micro-CT can be used to characterize:

  • Bone loss and growth

  • Bone density and microstructure

  • 骨重塑和钙化

We also have strong expertise in imaging of bone metastasis in validated intracardiac and peritibial models, including imaging of osteolytic and osteoblastic activity, using staged-treatment or prevention paradigms.


我们有效地通过CT监测和量化原位肺肿瘤生长。我们提供三种肺部模型,使用人肿瘤细胞系,一个PDX肺模型和17种另外的肺肿瘤细胞系,每个肺肿瘤细胞系可以是荧光素酶,以便在一个中进行评估orthotopic setting.

Skeletal Phenotyping



3D tissue vasculature can be casted using curative-agent, perfusion protocols. Through ex vivo CT imaging, tissue vascular architecture can be visualized and analyzed for treatment effect. We use this powerful approach for assessment of anti-angiogenic therapies in肿瘤学模型.




对于腹部的3D CT图像,可以从瘦组织中察觉内脏脂肪以使身体成分终点。