Computed Tomography (CT)

Micro computed tomography (CT) imaging platform draws on expertise in implementing, developing, optimizing, and validating micro-CT imaging paradigms for drug research studies. Our experience in CT-based bone and soft tissue imaging encompasses a number ofdisease states.

In vivo micro-CT imaging enables high-resolution (to ~50 microns), three-dimensional image generation by rotation of an x-ray source and detector around an imaging subject. Multiple projections are obtained during the rotation and reconstructed to generate the three-dimensional image. The large density differences between bone, soft tissue, and air make them readily distinguished by CT. CT contrast between different soft tissues is generally more subtle. The use of systemically administered, CT contrast agents enables better visualization of the soft tissues, including the vascular system.

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CT is the preferred, translational technology for the quantification of metastatic and arthritic bone disease. We provide numerous, validated bone-disease models, including several models of bone metastasis and rheumatoid arthritis. Micro-CT can be used to characterize:

  • Bone loss and growth

  • Bone density and microstructure

  • 骨重塑和钙化

We also have strong expertise in imaging of bone metastasis in validated intracardiac and peritibial models, including imaging of osteolytic and osteoblastic activity, using staged-treatment or prevention paradigms.

骨转移

我们有效地通过CT监测和量化原位肺肿瘤生长。我们提供三种肺部模型,使用人肿瘤细胞系,一个PDX肺模型和17种另外的肺肿瘤细胞系,每个肺肿瘤细胞系可以是荧光素酶,以便在一个中进行评估orthotopic setting.

Skeletal Phenotyping

Micro-CT为骨骼建筑的3D分析提供了非破坏性成像。协议使骨骼特征的定量,形态学分析能够进行定量,形态学分析。

血管映射

3D tissue vasculature can be casted using curative-agent, perfusion protocols. Through ex vivo CT imaging, tissue vascular architecture can be visualized and analyzed for treatment effect. We use this powerful approach for assessment of anti-angiogenic therapies in肿瘤学模型.

用高密度固定/固化剂灌注后小鼠肝脏evivo
用高密度固定/固化剂灌注后小鼠肝脏evivo

微型CT成像提供了优于组织学的骨微结构的3D非破坏性分析。作为我们与您合作的一部分,可以在您的设施进行研究,我们可以筛选并分析样品。我们从样品收据提供一到两周的快速转变,包括完整的数据集,表格数据和报告。

微型CT成像非常适合于骨质疏松症的研究,例如,在老年女性啮齿动物模型中。通过时间课程成像可以研究骨保护处理范式。我们利用我们员工使用骨质疏松症的专业知识来满足特定需求。

对于腹部的3D CT图像,可以从瘦组织中察觉内脏脂肪以使身体成分终点。

我们可以快速执行新型CT造影剂和纳米颗粒的基于测试和基于图像的表征。

微型CT成像可以提供来自安全性和性能的植入生物材料和医疗器械的非侵入性,无损性能和测试。我们的外科专业知识可以容纳医疗器械或材料植入物在体内成像时间课程之前。