Focal radiation enhances paclitaxel therapy in a mouse model of triple negative breast cancer

作者:

Maryland Rosenfeld Franklin, Thomas Dailey, and Wilbur R. Leopold

年:

2017年

AACR年会

“局灶性辐射增强了三重阴性乳腺癌的小鼠模型中的紫杉醇疗法”

Introduction & Background:

  • 三重阴性乳腺癌(TNBC)占全国所有乳腺癌的15-20%。
  • Patients with TNBC have poorer prognosis and therapeutic intervention is more challenging due to insensitivity to
  • hormonal and anti-HER2 therapies.
  • Therapeutic options for TNBC can include chemotherapy and/or radiation (RT) treatment.
  • 评估较短的临床试验,乳腺癌患者进行较短的次次辐射辐射。
  • 该研究评估了紫杉醇的临床前活性与较低剂量,yaboapp体育官网更频繁的辐射或更高剂量,较少的辐射较少。