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oppts 870.7600：真皮渗透
Metabolism
Plasma protein binding (PPB) evaluations
录制类型：Evaluation
一旦药物被吸收到循环中，它可以与血浆蛋白结合。人类中的两个主要血浆蛋白质是血清白蛋白，其主要是结合中性和碱性药物和α1-酸糖蛋白，其主要是结合酸性药物（例如乙酰水杨酸 - 阿司匹林）。
血浆蛋白结合（PPB）影响药代动力学（PK）参数，特别是分布和间隙的体积。高PPB将药物的分区限制在血液中的分配到它们发挥治疗效果的组织中。
药物PPB形成药物的“储层”，延长半衰期，因为只能代谢免药。
Methods to assess PPB include equilibrium dialysis (most commonly used), ultrafiltration, ultracentrifugation, gel filtration, binding to albumin microspheres and circular dichroism. In equilibrium dialysis, a semi-permeable membrane separates a protein-containing compartment from a protein-free compartment and the test compound present in each compartment is quantified by liquid chromatography with tandem mass spectrometry (LC-MS-MS).
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