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Oligonucleotide quantitation
Bioanalysis, LC-MS, IChem
Oligonucleotide quantitation
Record Type:Analysis
Validation:GLP,Non-GLP,GCP
Models:Mouse,老鼠,Rabbit,Canine,Mini-pig,NHP,Other Model,人类
The quantitative analysis of molecules in a therapeutic “class” generally referred to as oligonucleotides (oligos, OGNs), but also referring to molecules such a small interfering-RNA (siRNA), micro-RNA (miRNA), aptamers, translation/ transcription blockers, etc.
As oligonucleotide-based drugs gain popularity, analysis of oligonucleotides has become an important element of drug development. Through UV spectroscopy-based quantitative analysis, one can characterize and catalog oligonucleotides and other molecules as well as identify impurities and other safety concerns.
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