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OECD 442C: Direct peptide reactivity assay (DPRA) for skin sensitization
Genetic, Acute, In Vitro Alternate
经合组织492：眼镜刺激和epiocular™（体外）
录制类型：测定
OECD 492：Epiocular™是一种用于眼睛刺激试验（EIT）的体外重建人角膜上皮（RHCE）模型，以评估测试物质的眼部危害。
Epiocular™通过确定细胞损伤，即细胞毒性效应，识别不需要对眼睛刺激或严重眼睛损伤进行分类和标记的化学品。这是基于前提，即所有这些物质将在角膜上皮和/或结膜中诱发细胞毒性，并符合联合国全球统一系统（UN GHS）。
Studies have found EpiOcular™ to have an overall accuracy of 80%. Test substances can be applied topically, so tissue exposures occur just as they do in vivo.
Related Capabilities
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OECD 432：体外光毒性（BALB / C 3T3）
Toxicology, In Vitro Alternate -
OECD 439: In vitro skin irritation (EpiSkin™ / EpiDerm™)
Toxicology, In Vitro Alternate -
OECD 493：人重组雌激素受体（HRER）
In Vitro Alternate -
OECD 442E：人体细胞系激活试验（H-Clat）
Toxicology, In Vitro Alternate -
OECD 455: Estrogen receptor transcriptional activation (ERTA)
毒理学，内分泌，体外替代 -
OECD 435: In vitro skin corrosion (Corrositex®)
Toxicology, In Vitro Alternate -
OECD 456: H295R Steroidogenesis assay
毒理学，内分泌，体外替代 -
OECD 437: BCOP (bovine corneal opacity permeability)
Toxicology, In Vitro Alternate -
经合组织438：孤立的鸡眼试验（具有任选的组织病理学）
Toxicology, In Vitro Alternate -
Cytoxicity assays for ISO/ICCVAM/HC: Balb/c C3T3; L929; MRC5
Toxicology, In Vitro Alternate -
经合组织492：眼镜刺激和epiocular™（体外）
Toxicology, In Vitro Alternate -
OECD 442D: KeratinoSens™ assay
Toxicology, In Vitro Alternate -
OECD 431：体外皮肤腐蚀（3D模型）
Toxicology, In Vitro Alternate -
Eye irritation
遗传，体外交替，急性
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。