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Immunotherapy: CAR T and TCR applications
药理学（安全）
Model: Humanized oncology
人源化肿瘤学小鼠模型由人外周血单核细胞（PBMC）或造血干细胞（HSC）移植到严重免疫的IMPROMISE NSG小鼠中，含有从人癌细胞系或人患者衍生的异种移植物（PDX）材料建立的肿瘤。
These models can then be used to screen immunotherapy agents against cancers and to explore the potential combinations of these agents to treat patients and predict outcomes.
Related Capabilities
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.了解有关我们对更换，重新塑造和炼制非临床研究模式的承诺。