体外替代试验方法

作物保护

科文斯致力于推动3R议程,因此,我们正在继续扩大和创新我们的体外测试,以评估作物保护产品。通过与我们合作,您将受益于我们丰富的执行标准技术的经验以及我们新颖的解决方案。我们将根据您的监管需求制定一种方法,并与您的物质的特定特性相一致。

体外

Proven expertise in delivering high-quality in vitro safety assessments

  • 超过20年的经验,在设计和执行一套全面的体外试验,以全球公认的标准
  • Innovators in in vitro study design and technology: enhancing study reliability and improving outcomes
  • Insights gathered from worldwide regulatory environments leveraged to smooth the regulatory journey of your crop protection product

你的需要

In vitro safety assessments

Multiple in vitro test methods are available for ascertaining the potential impact of your crop protection product on human safety; however how do you find the optimum approach to meet your needs? How can you best exploit in silico and in vitro testing to answer regulatory questions and meet ever-changing endpoints? You need a partner with insight and experience in in vitro test methods and their application to different global regulatory environments..


Our Capabilities

科文斯是在作物保护产品体外试验的前沿

Covance has played a role in validating various in vitro technologies. Staff engage proactively with the in vitro scientific community via membership of a range of professional bodies such as the in vitro toxicology society (IVTS), in vitro testing industrial platform (IVTIP) and the European Society of Toxicology In Vitro (ESTIV).

这使科文斯在体外方法和创新的前沿,产生的见解,使您作为我们的合作伙伴受益。

与致力于提供体外试验成功的专家团队合作

科文斯体外试验团队由来自不同背景的专家组成,他们在计划和管理体外试验方面拥有丰富的经验。这个团队包括毒理学家、生物学家、分析化学家和环境科学家。通过合作,学习计划可以灵活和优化,以满足您的需求和时间表。

让科文斯利用其广泛的体外测试能力,可靠地描述您的作物保护产品的安全概况

Covance conducts approximately 400 in vitro toxicology studies each year covering the following:

Phototoxicity

Balb/c 3T3

经合组织432

Cytotoxicity

Balb/c;L929;MRC5

ISO/ICCVAM/HC

皮肤腐蚀

三维模型

经合组织431

Corrositex®

经合组织435

皮肤刺激

三维模型

经合组织439

眼睛Irritation

BCOP

经合组织437

Isolated Chicken Eye Test (with optional histopathology)

经合组织438

EpiOcular™

OECD 492

Skin Sensitization

直接肽反应性测定(DPRA)

OCED 442C

角蛋白™ 化验

OCED 442D

Human Cell Line Activation Test (hCLAT)

OCED 442E

内分泌Disruption

Estrogen receptor agonist/antagonist

经合组织455

H295R类固醇生成测定

经合组织456
Androgen receptor (AR Calux®) agonist/antagonist 经合组织458

Human Recombinant Estrogen Receptor (hrER)

OECD 493

*如有正当理由,可提供体内皮肤致敏(OECD 429)