.png){kind=icon}
Custom Antibody Reagents
为您提供端到端的服务，以产生针对各种宿主物种中各种抗原类型的抗体试剂。
Custom Antibody Capabilities
For nearly five decades, we’ve been refining services and capabilities to help you manage the entire antibody development process.
Choose from a comprehensive set of suite of services including:
- Polyclonal & monoclonal antibody production
- Purification, labeling and characterization of antibodies
- 非GLP测定鉴定和样品分析的杂交瘤生成，表征和扩大
因为没有两项研究是相似的，你会得到一套服务，围绕您的特定需求
从完整的自定义工具组合和关键抗体试剂开发服务中选择，同时执行其他nonclinical studies在景气。我们提供区域和全球解决方案，以帮助您访问：
工具抗体试剂
Tool antibody reagents are standard antibody generation services for use in characterization of the target in basic/academic settings or exploratory drug discovery research.
服务包括单克隆和多克隆抗体生产从几毫克大量到大量。
关键抗体试剂
Critical antibody reagents are used in a regulated drug development setting and include both polyclonal and monoclonal anti-drug antibodies, anti-idiotypic antibodies and anti-host cell protein antibodies. These reagents are generated with extensive documentation, additional levels of characterization and often larger quantities to last for the duration of the product's lifecycle.
多克隆抗体
定制抗体服务的完整组合包括肽合成，抗体生产，缀合，纯化，标记和表征。产生多克隆抗体涉及三个阶段：免疫，监测免疫应答和抗原特异性亲和纯化。每个步骤都是可定制的，我们将与您一起使用以创建优化的生产计划，以最大化血清体积和抗体滴度。
Monoclonal Antibodies
A full range of production services are available in diverse rodent strains. You can choose in vivo或体外生产方案，根据您的需求调整小型或大量的协议。
Anti-Idiotype Antibodies
作为定制抗身抗体发育的领先提供商，我们的团队将为您的反身份项目带来独特的科学专业知识，如：
- BiothyApputics和大分子
- 全长或截短的抗体
- F（AB'）2，Fab和单链抗体碎片
By partnering with us, you will benefit from our extensive capabilities in generating capture reagents forPK/TK studies，用于中和测定和抗原成像的阳性对照。
Hybridomas
Generate hybridomas against a large array of antigens and keep all cell lines developed by Covance as your exclusive property. Also, all four hybridoma development stages – immunization, fusion and screening, subcloning and clone stabilization – are customizable.
广泛的适用于任何尺寸的项目的体外/体内放大功能，您可以体验各种额外的免疫学服务。这些包括细胞系膨胀，PBMC隔离，同种型和支原体测试。
Anti-Host Cell Protein Antibodies (Anti-HCP)
由于在重组蛋白制剂中存在宿主细胞蛋白质，因此可以损害产品的安全性和质量，因此将这种污染降低到可能的最低水平至关重要。
抗HCP抗体发育包括捕获和检测的体内阶段，以及用于纯化，表征和缀合的体外阶段。第一阶段是我们拥有多种物种的广泛内部体验的支持，因此您可以选择最佳模型以满足您的独特要求。对于第二阶段，我们的专用免疫化实验室提供了各种可定制选项。
We can help you every step of the way, with our custom reagent and method development for anti-HCP assays:
- 定制试剂和方法开发
- 分析开发/瓦里dation (ELISA)
- 资格和验证
- 常规测试
- 测定转移
Anti-Drug Antibodies
By partnering with leading providers of custom ADA development, you will benefit from our scientific expertise across the development process as well as our extensive capabilities in custom reagent development and related ADA services, including development of PK, TK, and potency assays.
Our key skills involve generating positive control for PK/TK studies and capture reagents for potency assays. We have a dedicated immunochemistry lab providing protein A/G and/or antigen-specific purifications, along with various options for depleting cross-reactive antibodies.
无论您的目标是方法还是矩阵验证，或评估耐药性，测定灵敏度或最低要求稀释度，您都可以从全套ADA功能中选择这些分子类型，如：
- BiothyApputics和大分子
- 全长或截短的抗体
- 肽
- 各种佐剂