They are not something most of us think about until something goes wrong. They filter 53 gallons of blood per day, remove toxins and excess volume from your blood, and help control other things like blood pressure and hemoglobin counts. They are our kidneys: two fist-sized bean-shaped organs that keep you healthy by making sure your blood remains in metabolic balance. Once a patient approaches kidney failure, we hope to get them a kidney transplant, but the reality is that the majority of patients undergo dialysis simply because there are not enough donated kidneys to go around. Either dialysis or a kidney transplant is needed to survive once kidney function is so poor that it needs replacement therapy.
An estimated 33 percent of American adults are at risk for developing kidney disease, including people who have diabetes, high blood pressure, and possibly those who are overweight.Chronic kidney disease (CKD)patients often remain asymptomatic, so those afflicted won’t know they have it until these vital organs reach a later stage of dysfunction. Unfortunately, the lack of proper screening for CKD contributes to the high rates of unawareness among CKD patients themselves. Additionally, the most common cause of morbidity and mortality in CKD patients is cardiovascular disease, which further highlights the critical need for early CKD diagnosis.
National Kidney Month一项致力于提高对肾病风险和鼓励筛查，预防和良好健康习惯的时间，每次三月都在美国观察到患有肾脏疾病的风险。在许多其他国家举行类似的观察。
This year,LabCorpis continuing to partner with the国家肾脏基金会（NKF）, on its new “Are You the 33%？“公众意识运动，专注于美国成年人的三分之一，以冒险开发CKD。通过一个简单的60秒肾脏风险测验，你可以学习你是否没有风险，并且通过与医生交谈开始的东西。如果您处于危险之外，将两个简单的测试组合成一个，称为肾面板，可衡量尿液中的血清肌酐和蛋白质。Labcorp几年前支持肾脏面板的推出，提高意识和早些时候检测CKD的能力。测试简单，结果对您的护理和管理产生了深远的影响。
我是一个成人肾脏仍关心慢性肾病patients as an adjunct professor at the University of North Carolina. I joined Covance in 2017 as the Nephrology Therapeutic Area head. I also serve on the Board of Directors for the Kidney Health Initiative, working to promote innovation and patient-focused drug development for people living with kidney disease.
For me, CKD is personal. Two of my cousins were diagnosed with end-stage kidney disease at ages 40 and 42, and their experiences demonstrate that there is so much more work to do.
肾脏疾病索赔的生活比乳腺癌和前列腺癌更合适，但它是一个公认的流行病。去年特朗普政府签署了一项执行命令，将直接Medicare制定促进预防性肾脏护理的支付模型，并增加移植和家庭透析的使用。其中三个主要目标是将肾脏衰竭的人数减少25％，到2030年，移植的肾脏的数量增加了两倍，并确保80％的肾功能衰竭患者通过2025年接受移植或家庭透析。
去年，美国FDA批准了近18年的糖尿病肾病（DKD）的第一部新建治疗方法：canagliflozin, an SGLT-2 Inhibitor. In addition to ongoing studies for DKD, there are more trials than ever across the different etiologies of CKD, including the investigation of new agents for glomerular disease, which includes focal segmental glomerulosclerosis, or FSGS, and immunoglobulin A nephropathy, commonly known as IgAN.
LabCorp联合NKF和其他器官izations to remove barriers to testing, help standardize tests used to detect CKD, improve comparison of test results between laboratories, increase early recognition and promote patient awareness. Diagnostics also offers a guideline-based clinical decision support program to assist providers, as well as patient education materials to help improve patient awareness and understanding of this disease.
I recently had the pleasure of collaborating with my LabCorp colleagues on an analysis of patients who had been tested at a LabCorp facility between January 2013 and December 2019. The study looked at data from more than 28 million patients to evaluate the frequency of guideline-recommended kidney-disease screening among at-risk patients. To our knowledge, this is the largest retrospective analysis of kidney disease screening rates in the United States.
结果是松散的。我们发现，在我们的研究中，只有17.4％的风险性质对慢性肾病进行了足够的筛查。该数据突出了需要改进筛选和检测的策略以及改善患者和医生意识的必要性。这项工作将作为一张海报分享，每年的NKF春季临床会议 - 现在已经被举行，海报将在美国肾病中发表，我们将与NKF进行未来的出版物以及努力进一步合作增加CKD患者入学肾试验。NKF正在推出患者的第一个全国CKD登记处，作为指导委员会成员，我希望能够帮助进展，以提高CKD患者的认识和审判参与的共同目标。
我的同事和我致力于加强检测和调查最终将其掌握在CKD患者手中的新治疗方法。我们的临床实验室数据库为临床试验设计和患者招聘策略提供了有价值的见解。
如果你take the quizand find that you are one of the 33 percent, visit your doctor and request that they perform urine and serum creatinine tests. And if you’re not among the 33 percent, consider signing an organ donation card. It’s one of the best things you can do to improve the outlook for people living with kidney disease.
