乳腺癌被认为是低免疫原性tumors, however, several approaches utilizing immunotherapies are being undertaken in the clinic to evaluate their potential for improving outcomes. Radiation therapy (RT) is a highly utilized clinical treatment modality in breast cancer. Radiation is known to modify the tumor microenvironment, induce cytokines and chemokines, and has been shown to potentially synergize with immunotherapies.
During AACR’s Annual Meeting 2016, Maryland Franklin, PhD, Vice President, Scientific Development, presented her poster session on this subject. The aim of the work was to evaluate the possible synergy between RT and anti‐CTLA‐4 therapy in a murine model of breast cancer.
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