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通过吸入暴露于作物保护化学物质对人类健康构成潜在风险。对于工人安全来说，这尤其如此，因为暴露水平远远高于消费者的曝光率。制备溶液，通过粉尘或喷涂施用，施加后的设备清洁，甚至是作物收获和加工，都是无意中吸入的机会。暴露风险通常是急性或亚急性，但毒性效应可以是急性或慢性的，特别是对于呼吸系统来说。
由于这些原因,吸入研究委托人y components of the toxicology studies in regulatory submissions for new agrochemical registrations and, often, for renewals. Additionally, inhalation data are used in establishing dose levels for other regulatory studies:人类风险评估如工人重新进入研究和方面，如labelingand packaging.
Labcorp可以为广泛的评估提供吸入毒理学安全服务，他们是标准的研究或小说需要创新的方法和独特的送货设备。
吸入毒理学对农作物保护产品的研究可以复杂，需要独特的解决方案
吸入agrochemic毒理学安全性研究als pose unique challenges and complexities. To maintain steady dosing in a breathing zone over many hours, and on multiple occasions in some studies, requires highly specific delivery systems. Accordingly, you need to tailor studies to your agrochemical and optimize them for its physiochemical properties to meet regulatory endpoints. You may need to refine standard test approaches to optimize study integrity, and need to provide justifications for any refinements. This means partnering with a team you can trust to design and run your inhalation toxicology studies to match your needs and the needs of your agrochemical.
一种吸入毒理学团队，具有广泛而多样化的作物保护专业知识
Our inhalation toxicology team comprises experts from diverse backgrounds and with extensive experience in planning and running inhalation toxicology studies for agrochemicals. The team includes animal welfare specialists, vets, pathologists, study managers, engineers, aerosol technologists, chemical analysts, and inhalation science toxicology experts. With regulatory scientists on hand to provide advice on regulatory compliance.
Performing recognized inhalation studies for crop protection products that deliver reliable, robust results
我们在进行常见吸入毒理学研究方面有经验：
- A full range of endpoints including acute and chronic
- Inhalation carcinogenicity and neurotoxicity
- 用新型应用或多达24小时/天的研究
- 胚胎，一代（EGRTS）和二代生殖研究
创新以解决您的特定农业化学挑战
Sometimes standard approaches don’t work — that’s when our ‘first of a kind’ inhalation toxicology mindset can create a solution suited to your unique challenge. This may be to address unusual endpoints or it may mean customizing inhalation delivery equipment to ensure regulatory acceptance. This could be via custom-built aerosol generation devices, inhalation chambers or sampling equipment, or even by 3D printing face masks specific to individual test animals. As your partner, we can innovate and enhance standard study approaches to optimize them for your agrochemical.
利用最先进的分析技术和设施来生产高质量的数据
Working hand in hand with inhalation-specific analytic scientists, the inhalation toxicology team ensures high-quality data for your crop protection product is produced in an appropriate timescale. Analytical approaches include GC, IR, photometers, UPLC and HPLC analysis and compound specific analysis. Lung-burden analysis and bronchoalveolar lavage are carried out as well as clinical observations and pathology studies.
High welfare standards assured
We are proud of the high welfare standards observed in all our in vivo work and especially in inhalation studies. An expert team of animal technicians and veterinarians ensures the highest levels of animal care in the design and conduct of studies. Inhalation studies for agrochemicals can be performed on the following species:
- 鼠
- 鼠
- 兔子
- 鹌鹑
为您的农业化学信息进行全面的吸入毒理学研究
我们的标准吸入毒理学研究套件crop protection chemicals includes:
- OECD 403 / OCSPP 870.1300：急性吸入毒性
- 经合组织433.: Acute inhalation study (fixed concentration)
- 经合组织412.: Inhalation toxicity study (subacute, 28-day)
- OECD 413/OCSPP 870.3465：吸入毒性研究（Subchronic，90天）
As well as standard studies, we can perform non-standard and tailored inhalation studies. Chronic toxicity and carcinogenicity and DART (developmental and reproductive toxicology) studies by the inhalation route are also available.
慢性毒性和致癌性研究：
- OECD 451/OCSPP 870.4200: Carcinogenicity studies
- OECD 452/OCSPP 870.4100: Chronic toxicity studies
- OECD 453/OCSPP 870.4300: Combined chronic toxicity/carcinogenicity studies
飞镖研究：
- 经合组织414.: Prenatal developmental toxicity study
- 经合组织443.: Extended one-generation reproductive toxicity study (EOGRTS)
- 经合组织416.: Two-generation reproduction toxicity
- 经合组织421.: Reproduction/developmental toxicity screening test
- 经合组织422.: Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test
Genotoxicity studies:
