In an age where new chemical entity drug development can average 15 years to complete and only 0.1% of drugs advance from early drug discovery to approval, a different approach is needed to address a pandemic like COVID-19. “Drug repurposing” and the request of an Emergency Use Authorization (EUA) are …
Non-compartmental analysis of pharmacokinetic data: considerations to gain efficiencies and meet SEND requirements
Pharmacokinetic (PK) data gathered in the early phases of drug discovery program can provide insights on a compound’s mechanism of action, identify specific attributes of interest and guide decision points to optimize downstream development. Selecting the most appropriate analysis technique is essential to computing PK parameters. This article discusses how …