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Toxicology|Immunotoxicology|Antibodies|Monoclonal|Polyclonal

Cytokine release assay

Record Type:Assay

Validation:Non-GLP

Models:NHP,Human

In vitro assay available in numerous formats to test for the ability of test articles (notably monoclonal antibodies) to elicit cytokine production from immune cells.

Related blog posts:

  • In vitro cytokine release assays: Is there calm after the storm? Part 1
  • 5 different kinds of cytokine release assays: Weathering the storm Part 2

Industry Market

Pharma

Phase

Nonclinical

Related Capabilities

  • OECD 442C: Direct peptide reactivity assay (DPRA) for skin sensitization

    Genetic, Acute, In Vitro Alternate
  • OECD 432: In vitro phototoxicity (Balb/c 3T3)

    Toxicology, In Vitro Alternate
  • OECD 439: In vitro skin irritation (EpiSkin™ / EpiDerm™)

    Toxicology, In Vitro Alternate
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About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC.Learn more about our commitment to replacing, reusing and refining nonclinical research models.

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